From 1921 to 1933, WIZO focused on developing its work in Palestine and in the Diaspora. From 1933 and during World War II we witnessed the annihilation of Jewish communities in Europe and the dissolution of WIZO Federations in countries under the Nazi scourge. This was also the era when 19 new Latin American WIZO Federations were created. The post war period was one of resuscitation of WIZO Federations and groups in Europe.

In 1949, following the establishment of the State of Israel, the WIZO Head Office was transferred from London to Israel and Rebecca Sieff was elected 1st President of the World WIZO Movement. She served as President till 1966. She was followed by Rosa Ginossar who was elected Chairman of the World WIZO Executive in 1951 and then President in 1966. In 1970, Raya Jaglom was elected President and served in this capacity till 1996. During her term of office, WIZO was established in the U.S. in 1982. During this period, WIZO was recognized by the United Nations as an N.G.O. with consultative status with Ecosoc and Unicef.

In 1996, Michal Modai was elected President of World WIZO and today Helena Glaser serves as World President. Tova Ben Dov is the current Chairman of World Wizo. In these 90 years since its establishment WIZO has created a social welfare network of over 800 institutions that cover the needs of the people of Israel.